
'The problem with the field of molecular evolution is that we have no molecular palaeontology, and not much in the way of comparative molecular biology. It is as if we only had a single specimen of a single species - one horse, for example - and we had to try and reconstruct the whole history of life from that one specimen, with no fossil record and no other organisms to compare it with. This is pretty much the situation we have in trying to understand how ATP-synthase came into existence. For all their external variety, this machine is pretty much identical in every living organism. If it evolved from something simpler, then we have no trace of what is was. For all that we think that bacteria, for example, are immeasurably simpler organisms than us, at the molecular level they are fantastically sophisticated and highly evolved. If we are to believe in an evolutionary origin of life, then we have to accept that there were billions of years in which molecular soft machines were evolving from unknown primitive forms to their current state of perfection, a process of evolution that has left no trace whatsoever. We have, not so much a missing link, as a completely missing history.' (page 121).